{"product_id":"abcam-ab216312","title":"Abcam, ab216312, Dovitinib, class III-V receptor tyrosine kinase inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 392.4 Da, Purity \u0026gt;99%. Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC 50  = 1 nM), c-KIT (IC 50  = 2 nM), FGFR (IC 50  = 8 nM), VEGFR1\/2\/3 (IC 50  values are 10 nM, 13 nM and 8 nM respectively), PDGFRβ (IC 50  = 27 nM), and CSF-1R (IC 50  = 36 nM). Selectively blocks growth of B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:392.4 Da,\u003cbr\u003e\nMolecular formula:C21H21FN6O,\u003cbr\u003e\nPubChem:9886808,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO (up to 30 mg\/ml),\u003cbr\u003e\nBiochemical name:CID 9886808,\u003cbr\u003e\nBiological description:Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1\/2\/3 (IC50 values are 10 nM, 13 nM and 8 nM respectively), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM). Selectively blocks growth of B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.,\u003cbr\u003e\nCanonical smiles:CN1CCN(CC1)C2=CC3=C(C=C2)NC(=C4C(=C5C(=NC4=O)C=CC=C5F)N)N3,\u003cbr\u003e\nIsomeric smiles:CN1CCN(CC1)C2=CC3=C(C=C2)N\/C(=C\/4\\C(=C5C(=NC4=O)C=CC=C5F)N)\/N3,\u003cbr\u003e\nInChi:InChI=1S\/C21H21FN6O\/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29\/h2-6,11,24-25H,7-10,23H2,1H3\/b20-18-,\u003cbr\u003e\nInChiKey:KCOYQXZDFIIGCY-ZZEZOPTASA-N,\u003cbr\u003e\nIUPAC Name:(3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847480823977,"sku":"ab216312","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab216312","provider":"Iright","version":"1.0","type":"link"}