{"product_id":"abcam-ab216313","title":"Abcam, ab216313, LY2874455, FGF\/FGFR inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 444.3 Da, Purity \u0026gt;98%. Potent FGF\/FGFR inhibitor. Inhibits  in vitro  autophosphorylation of FGFR-1, FGFR-2, FGFR-3, and FGFR-4 with similar inhibition potency for all four FGFRs (IC 50  \u0026lt; 6.4 nM). Exhibits a 6- to 9-fold  in vitro  and  in vivo  selectivity on inhibition of FGF- over VEGF-mediated target signaling in mice.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1254473-64-7,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:444.3 Da,\u003cbr\u003e\nMolecular formula:C21H19Cl2N5O2,\u003cbr\u003e\nPubChem:46944259,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:DMSO (\u0026gt;4 mg\/ml),\u003cbr\u003e\nBiochemical name:LY-2874455,\u003cbr\u003e\nBiological description:Potent FGF\/FGFR inhibitor. Inhibits in vitro autophosphorylation of FGFR-1, FGFR-2, FGFR-3, and FGFR-4 with similar inhibition potency for all four FGFRs (IC50 \u0026lt; 6.4 nM). Exhibits a 6- to 9-fold in vitro and in vivo selectivity on inhibition of FGF- over VEGF-mediated target signaling in mice.,\u003cbr\u003e\nCanonical smiles:CC(C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3C=CC4=CN(N=C4)CCO,\u003cbr\u003e\nIsomeric smiles:C[C@H](C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3\/C=C\/C4=CN(N=C4)CCO,\u003cbr\u003e\nInChi:InChI=1S\/C21H19Cl2N5O2\/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29\/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)\/b4-2+\/t13-\/m1\/s1,\u003cbr\u003e\nInChiKey:GKJCVYLDJWTWQU-CXLRFSCWSA-N,\u003cbr\u003e\nIUPAC Name:2-[4-[(E)-2-[5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 9532 LY-2874455. 9532-25 is the same size as the 25 mg size of ab216313.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nInterferon beta also called IFN-β is a cytokine produced by fibroblasts and immune cells like macrophages. It has a molecular mass of approximately 20 kDa. You can find it expressed in various tissues including spleen liver and lung. As a type I interferon its main role is to regulate the immune response especially during viral infections.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nInterferon beta works by inhibiting viral replication within host cells. It does so by triggering a complex signaling cascade via the JAK-STAT pathway. This cascade induces the expression of interferon-stimulated genes (ISGs) which boost the antiviral state of cells. Moreover Interferon beta modulates immune functions and inflammation contributing to its therapeutic roles in immune-related disorders.\u003cbr\u003e\nPathways\u003cbr\u003e\nInterferon beta activates the JAK-STAT signaling and also impacts MAPK pathways. These pathways regulate not only antiviral responses but also cell proliferation and apoptosis. Interferon beta interacts closely with other proteins in these pathways such as Signal Transducer and Activator of Transcription 1 (STAT1) and STAT2 leading to enhanced antiviral and immunomodulatory effects.\u003cbr\u003e\nInterferon beta plays a significant role in the management of multiple sclerosis and hepatitis C. In multiple sclerosis it helps modulate the immune system to prevent harmful autoimmunity. Interferon beta's action involves reducing the activity of pro-inflammatory cytokines and improving the balance with anti-inflammatory cytokines. The protein also has a connection with Viral Hepatitis via interactions with viral RNA making it a critical component of antiviral therapy.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847430394025,"sku":"ab216313","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab216313","provider":"Iright","version":"1.0","type":"link"}