{"product_id":"abcam-ab216405","title":"Abcam, ab216405, Anti-Gastrin Releasing Peptide antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal GRP antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Gastrin-releasing peptide conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human Gastrin-releasing peptide conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P07492\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGastrin-Releasing Peptide (GRP) also known as the bombesin-like peptide is a 27-amino acid peptide with a molecular mass of approximately 3 kDa. GRP is synthesized in the gastrointestinal tract where it plays a role in the regulation of gastric acid secretion and gut motility. It is also expressed in the central nervous system especially in regions associated with sensory and autonomic functions. The peptide's expression in neuroendocrine cells further signifies its involvement in neurotransmitter and hormone release.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGRP functions in stimulating the release of gastrin a hormone that promotes gastric acid secretion and mucosal growth. It does not act in isolation; instead GRP often forms part of a neuropeptide network that influences gastric functions and energy metabolism. Additionally it modulates inflammatory responses and cellular communication in tissues where it is active. This diverse range of functions highlights the peptide's role in maintaining physiological balance.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe gastrin-releasing peptide engages primarily in the gastrin-related pathways which involve gastric acid secretion. GRP acts upstream of the pathway by binding to its receptor the GRP receptor (GRPR) promoting the release of gastrin from G cells. Interaction with other proteins in this system such as cholecystokinin and secretin help regulate digestive functions. Additionally GRP is a part of the signaling pathways that influence the release of insulin and other hormones that are pivotal to digestive efficiency.\u003cbr\u003e\nGRP has associations with certain cancers like prostate cancer and small cell lung cancer where it acts as an autocrine growth factor. These cancers often show elevated levels of GRP suggesting its role in cancer cell proliferation. Furthermore higher levels of GRP may link to inflammatory bowel disease as it modulates immune and inflammatory responses in the gut. In these contexts GRP interacts with proteins involved in tumorigenesis and inflammation providing potential targets for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848524976297,"sku":"ab216405","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab216405","provider":"Iright","version":"1.0","type":"link"}