{"product_id":"abcam-ab216471","title":"Abcam, ab216471, IKK-16, IkappaB kinase inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 520.1 Da. Potent, selective IκB kinase (IKK) inhibitor (IC 50  values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM. Inhibits LPS-induced TNF-α release  in vivo  and neutrophil extravasion in thioglycollate-induced peritonitis.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1186195-62-9,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:520.1 Da,\u003cbr\u003e\nMolecular formula:C28H30ClN5OS,\u003cbr\u003e\nPubChem:56972179,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:IKK 16 (hydrochloride),\u003cbr\u003e\nBiological description:Potent, selective IκB kinase (IKK) inhibitor (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM. Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.,\u003cbr\u003e\nCanonical smiles:C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl,\u003cbr\u003e\nInChi:InChI=1S\/C28H29N5OS.ClH\/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;\/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31);1H,\u003cbr\u003e\nInChiKey:XFVDIVQCZWDBCW-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;hydrochloride\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B1087 IKK16. B1087-25 is the same size as the 25 mg size of ab216471.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847421055145,"sku":"ab216471","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab216471","provider":"Iright","version":"1.0","type":"link"}