{"product_id":"abcam-ab217033","title":"Abcam, ab217033, Anti-TRAF3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TRAF3 antibody. Suitable for IHC-P, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TRAF3 aa 100-200 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human TRAF3 aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q13114\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRAF3 also known as TNF receptor-associated factor 3 weighs approximately 63 kDa. This adaptor protein is expressed in many tissues including lymphoid organs and the spleen. Mechanically TRAF3 interacts with the tumor necrosis factor receptor (TNFR) superfamily serving as a pivotal mediator in transducing signals. The protein engages directly with cytoplasmic domains of receptors relaying information downstream to influence cellular responses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein TRAF3 influences immune response regulation and lymphocyte activation by being part of signaling complexes. It binds with other TRAF family members forming multimeric structures for modulating NF-kB and MAPK pathways. TRAF3 plays a role in both adaptive and innate immune mechanisms controlling cell survival signals and apoptosis. Its activity impacts B-cell and T-cell functions further emphasizing its role in immune cell dynamics.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRAF3 significantly impacts NF-kB activation and MAP kinase signaling. It cooperates with other proteins like TRAF2 and NIK to modulate these pathways. The NF-kB pathway important for immune and inflammatory responses involves TRAF3 in negatively regulating this pathway by targeting NIK for degradation. Similarly in the MAPK signaling TRAF3 influences response to environmental stresses.\u003cbr\u003e\nTRAF3 connects to conditions such as autoimmune diseases and lymphoma. In autoimmune diseases the improper function of TRAF3 affects immune tolerance leading to abnormal B-cell activity. In lymphomas TRAF3 mutations can result in loss of function contributing to the development of B-cell malignancies. Interactions with proteins like TRAF2 in these disorders illustrate its significance in pathology and potential targeting in therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850102067369,"sku":"ab217033","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab217033","provider":"Iright","version":"1.0","type":"link"}