{"product_id":"abcam-ab217345","title":"Abcam, ab217345, Anti-CD63 antibody [EPR21151]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-CD63 antibody [EPR21151] (ab217345) is a rabbit monoclonal antibody detecting CD63 in  Western Blot, ICC\/IF . Suitable for  Mouse . - Biophysical QC for unrivalled batch-batch consistency - Over 140 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR21151,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nProduct Specifications\u003cbr\u003e\nAnti-CD63 antibody [EPR21151] (ab217345) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC\/IF, WB in mouse samples.\u003cbr\u003e\nAnti-CD63 antibody [EPR21151] (ab217345) specifically detects CD63 (UniProt ID: P41731; Molecular weight: 26kDa) and is sold in 100 µL and 1 mL selling sizes.\u003cbr\u003e\nQuality and Validation\u003cbr\u003e\nAbcam's high quality manufacturing and validation processes ensure Anti-CD63 antibody [EPR21151] (ab217345) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.\u003cbr\u003e\nAnti-CD63 antibody [EPR21151] (ab217345) has been cited over 147 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAnti-CD63 antibody [EPR21151] (ab217345) has 5 independent reviews from customers.\u003cbr\u003e\nRelated Products\u003cbr\u003e\nConjugation-ready, carrier free format available for antibody clone EPR21151 -\u003cbr\u003e\nab227892\u003cbr\u003e\nAntibody clone EPR21151 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, APC, PE, Alexa Fluor® 594, Alexa Fluor® 555 (\u003cbr\u003e\nab233055\u003cbr\u003e\nab233056\u003cbr\u003e\nab319310\u003cbr\u003e\nab319449\u003cbr\u003e\nab319803\u003cbr\u003e\nab319944\u003cbr\u003e\nTarget Information\u003cbr\u003e\nCD63, also known as LAMP3 or Granulophysin, is a member of the tetraspanin family and is widely expressed on the surface of various cells, including macrophages and lymphocytes. It plays a crucial role in the formation and release of exosomes. CD63 (Granulophysin) is highly expressed in various tumor cells and also impacts the tumor microenvironment (TME) by regulating cell communication. Additionally, CD63 facilitates the degradation of the extracellular matrix, aiding in tumor cell invasion and metastasis.\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nHuman, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCD63 is a protein commonly known as LAMP-3 a member of the tetraspanin family with a molecular weight of approximately 25-65 kDa depending on post-translational modifications such as glycosylation. It resides mainly on the membrane of intracellular vesicles such as lysosomes and platelets. CD63 also appears on the surface of activated cells particularly in immune cells. Researchers often use CD63 as a marker in assays including CD63 western blot techniques due to its distinct expression patterns.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCD63 participates in various cellular processes including membrane trafficking cell adhesion and signal transduction. It associates with integrins and other tetraspanins forming complexes that influence cellular adhesion and migration. Through its role in exosome formation CD63 contributes significantly to intercellular communication by facilitating the transfer of proteins lipids and RNA between cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nCD63 plays a role in pathways linked to cell proliferation and migration and immune response regulation. Within the integrin-mediated signaling pathway CD63 interacts with proteins such as integrins to promote cell adhesion and migration. CD63 also links to vesicle trafficking pathways collaborating with proteins involved in exocytosis and endocytosis which affect cell membrane restructuring and intracellular transport.\u003cbr\u003e\nCD63 shows connections with cancer and immune system disorders. Its role in promoting cell adhesion and migration links it with cancer metastasis including melanoma and breast cancer where CD63 expression levels often rise. Additionally CD63 associates with allergic reactions due to its involvement in histamine release where it impacts immune proteins like FcεRI which participate in allergy pathogenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844079145129,"sku":"ab217345","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab217345","provider":"Iright","version":"1.0","type":"link"}