{"product_id":"abcam-ab217828","title":"Abcam, ab217828, Recombinant Human HtrA3 protein (His tag)","description":"\u003cp\u003eSize: 20µg \/ 50µg\u003cbr\u003e\nRecombinant Human HtrA3 protein (His tag) is a Human Fragment protein, in the 132 to 353 aa range, expressed in Escherichia coli, with \u0026gt;95%, suitable for SDS-PAGE, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% Densitometry,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P83110,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7Preservative: 1.02% ImidazoleConstituents: 10% Glycerol (glycerin, glycerine), 1.74% Sodium chloride, 0.79% Tris HCl\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHtrA3 also known as high temperature requirement A3 is a serine protease that regulates protein quality control by degrading misfolded or damaged proteins. With a molecular mass of approximately 50 kDa HtrA3 is expressed in a variety of tissues including placenta lung and heart. Expression levels vary in different cell types which indicates a diverse role. The active form of HtrA3 often results from the removal of its N-terminal inhibitory domain allowing it to target specific substrates for degradation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHtrA3 plays a role in cellular stress response and apoptosis regulation. This protein engages in mitochondrial pathways to exert its pro-apoptotic effects. HtrA3 often functions independently rather than as part of a complex although its influence on pathways can involve interactions with other proteins pivotal to cell survival. In cellular stress conditions HtrA3 modulates the stability and function of key proteins involved in apoptosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nOne critical interaction includes HtrA3's involvement in the modulation of the TGF-beta signaling pathway which plays a significant role in cell proliferation and differentiation. HtrA3 may interact with proteins such as Smad proteins within this pathway to influence cellular outcomes. Additionally HtrA3 can impact the oxidative stress response through its proteolytic activity affecting proteins involved in the reduction of oxidative damage.\u003cbr\u003e\nAberrant HtrA3 expression links to cancer and cardiovascular diseases. Reduced levels of HtrA3 have been observed in various cancers including ovarian cancer where low expression may correlate with poor prognosis. Moreover alterations in HtrA3 expression impact cardiovascular health potentially connecting with proteins like p53 which is important for the cellular stress responses in these disorders. Understanding HtrA3's roles can provide insight into its potential as a biomarker or therapeutic target in these disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843969470633,"sku":"ab217828","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab217828","provider":"Iright","version":"1.0","type":"link"}