{"product_id":"abcam-ab218610","title":"Abcam, ab218610, GSK343, histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 541.7 Da, Purity \u0026gt;99%. Potent, selective, cell-permeable histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor. Inhibits EZH2 enzymatic activity (IC 50 =  4 nM). Displays 60 fold selectivity for EZH2 over EZH1, and 1000 fold or greater selectivity against other histone methyltransferases. Inhibits H3K27 methylation in HCC1806 cells (IC 50  \u0026lt; 200 nM).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1346704-33-3,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:541.7 Da,\u003cbr\u003e\nMolecular formula:C31H39N7O2,\u003cbr\u003e\nPubChem:71268957,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide,\u003cbr\u003e\nBiological description:Potent, selective, cell-permeable histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor. Inhibits EZH2 enzymatic activity (IC50 = 4 nM). Displays 60 fold selectivity for EZH2 over EZH1, and 1000 fold or greater selectivity against other histone methyltransferases. Inhibits H3K27 methylation in HCC1806 cells (IC50 \u0026lt; 200 nM).,\u003cbr\u003e\nCanonical smiles:CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C,\u003cbr\u003e\nInChi:InChI=1S\/C31H39N7O2\/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37\/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40),\u003cbr\u003e\nInChiKey:ULNXAWLQFZMIHX-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 2281 GSK343. 2281-5 is the same size as the 5 mg size of ab218610.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847497109673,"sku":"ab218610","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab218610","provider":"Iright","version":"1.0","type":"link"}