{"product_id":"abcam-ab219547","title":"Abcam, ab219547, Anti-Estrogen Related Receptor gamma antibody - C-terminal","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal Estrogen Related Receptor gamma antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ESRRG.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ESRRG. The exact immunogen used to generate this antibody is proprietary information.P62508,\u003cbr\u003e\nSpecificity:BLAST analysis of the peptide immunogen showed no homology with other Human proteins.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.099% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEstrogen Related Receptor gamma (ERRγ) also known as NR3B3 is a nuclear receptor that functions as a transcription factor. This protein regulates gene expression by binding to specific DNA sequences. ERRγ has a mass of approximately 51 kDa. It is expressed in various tissues including the heart skeletal muscle brain kidney and liver. As an orphan receptor ERRγ does not have a known endogenous ligand which impacts how it responds to different cellular signals.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nERRγ influences several important physiological processes. This receptor is involved in energy metabolism mitochondrial biogenesis and cellular differentiation. ERRγ often operates as part of a larger transcriptional regulatory complex interacting with co-regulators such as PGC-1α to modulate its activity. By binding to specific genes ERRγ modulates processes like glucose metabolism fatty acid oxidation and oxidative phosphorylation which are vital for cellular energy homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nERRγ plays a significant role in the regulation of energy homeostasis and mitochondrial function. It is an important player in the PGC-1α signaling pathway influencing the expression of genes involved in mitochondrial biogenesis and respiration. ERRγ interacts closely with Peroxisome Proliferator-Activated Receptor (PPAR) pathways enhancing the transcription of genes required for fatty acid metabolism. These interactions contribute to the adaptive response of cells to changes in energy demands and nutrient availability.\u003cbr\u003e\nERRγ associates with metabolic conditions and neurodegenerative diseases. Abnormal ERRγ activity has links to metabolic syndrome which includes obesity and diabetes highlighting its role in energy metabolism and insulin sensitivity. Additionally ERRγ expression changes in neurodegenerative disorders like Alzheimer's disease where it interacts with proteins like PGC-1α and influences neuronal survival and function. Understanding these associations might offer new therapeutic targets for managing these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854255837353,"sku":"ab219547","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab219547","provider":"Iright","version":"1.0","type":"link"}