{"product_id":"abcam-ab220039","title":"Abcam, ab220039, Anti-AFF4 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal AFF4 antibody. Suitable for ICC and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AFF4 aa 50-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human AFF4 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9UHB7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe AFF4 protein also known as AF4\/FMR2 family member 4 is a transcriptional cofactor with a molecular weight of approximately 140 kDa. It plays a role in regulating transcriptional elongation by RNA polymerase II. This protein shows expression across diverse tissues with higher levels in the brain and testis. AFF4 contains domains that enable interactions with other proteins facilitating its role in transcriptional regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAFF4 functions as a component of the super elongation complex (SEC) which is essential for transcriptional elongation of specific genes. This complex ensures efficient transcription after the initiation phase. Through its association with SEC AFF4 influences the expression of genes involved in cellular differentiation and development. Its activity is particularly impactful on genes associated with oncogenesis and neural development affecting cellular growth and specialized cell formation.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of AFF4 integrates into the transcription elongation and gene regulation pathways. AFF4 interacts with proteins like ELL2 and CDK9 which are critical components of the positive transcription elongation factor b (P-TEFb) complex. Together these proteins regulate polymerase activity and gene expression fundamental in cell cycle control and response to growth signals.\u003cbr\u003e\nAFF4 has connections to cancer and neurological disorders. Mutations or altered expressions of AFF4 relate to acute lymphoblastic leukemia where it may form fusion proteins that disrupt normal gene expression. In neurological contexts aberrant AFF4 function can contribute to disorders such as developmental delay. Through these diseases AFF4 interacts with disease-related proteins like MLL and AF9 involved in oncogenic transformations and neurological development respectively.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848633864361,"sku":"ab220039","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab220039","provider":"Iright","version":"1.0","type":"link"}