{"product_id":"abcam-ab220043","title":"Abcam, ab220043, Anti-RHBG antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal RHBG antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RHBG aa 350-400.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human RHBG aa 350-400. The exact immunogen used to generate this antibody is proprietary information.Q9H310\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRHBG also known as Rh family B glycoprotein is an ammonia transporter. This protein moves ammonia across cell membranes without the use of energy facilitating its passage in and out of cells. RHBG weighs approximately 53 kDa and is integral to membrane structure. You can find RHBG highly expressed in the kidney and liver where it performs its ammonia transport function efficiently. It also shows expression in parts of the gastrointestinal tract contributing to nitrogen metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRHBG functions as part of processes that regulate acid-base balance in the body maintaining homeostasis. Although not part of a larger complex RHBG works alongside other ammonia transporters such as its close relatives RHCG and RHAG to manage ammonium balance in tissues. This action is critical in waste excretion and nitrogen metabolism allowing proper cell function.\u003cbr\u003e\nPathways\u003cbr\u003e\nMechanisms involving RHBG play roles in the nitrogen metabolism and renal acid excretion pathways. In the kidney it operates closely with pathways that balance pH levels meaning it cooperates with proteins like RHCG to achieve effective regulation of ammonia levels within the renal system. These pathways support the safe removal of waste products from the body protecting against metabolic disorders caused by nitrogen imbalance.\u003cbr\u003e\nRHBG associates with conditions like hyperammonemia and certain kidney diseases. When RHBG function is impaired ammonia can accumulate leading to elevated blood ammonia levels contributing to various pathologies. In the context of kidney diseases RHBG disruption interferes with the body's ability to maintain proper acid-base homeostasis linking it to proteins such as RHCG and others involved in bicarbonate transport that help regulate kidney function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854234144937,"sku":"ab220043","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab220043","provider":"Iright","version":"1.0","type":"link"}