{"product_id":"abcam-ab220098","title":"Abcam, ab220098, Anti-DHTKD1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal DHTKD1 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DHTKD1 aa 1-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human DHTKD1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q96HY7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDHTKD1 also known as dehydrogenase E1 and transketolase domain containing 1 is a mitochondrial protein with a mass of approximately 100 kDa. Its role involves the catalysis of oxidative decarboxylation of 2-oxoadipate in the lysine and tryptophan degradation pathways making it important for mitochondrial energy metabolism. DHTKD1 expression occurs broadly in human tissues with higher levels in organs with high metabolic demands like muscle and liver.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDHTKD1 operates as part of the 2-oxoadipate dehydrogenase complex which is multi-enzymatic. This complex works in tandem to convert 2-oxoadipate into glutaryl-CoA an essential process in the catabolic pathways of lysine hydroxylysine and tryptophan. By working alongside other enzymes like dihydrolipoamide dehydrogenase DHTKD1 supports the intricate network of energy production and biosynthesis in cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nDHTKD1 plays a pivotal role in the lysine and tryptophan catabolic pathways contributing significantly to the production of ketone bodies and energy. It is closely related to proteins such as OGDH (oxoglutarate dehydrogenase) and BCKAD (branched-chain alpha-keto acid dehydrogenase complex) which participate in various metabolic cycles essential for cellular respiration and regulation of amino acid levels.\u003cbr\u003e\nDHTKD1 mutations have been linked to 2-aminoadipic and 2-oxoadipic aciduria a metabolic disorder characterized by the accumulation of 2-oxoadipate and L-2-hydroxyglutarate leading to developmental delay and motor dysfunction. It is also associated with Charcot-Marie-Tooth disease (CMT) where it may affect peripheral nerve function. Both conditions underline the protein's importance in maintaining metabolic and neurological health highlighting its interaction with other key proteins involved in mitochondrial dynamics and nervous system integrity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854206259369,"sku":"ab220098","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab220098","provider":"Iright","version":"1.0","type":"link"}