{"product_id":"abcam-ab223147","title":"Abcam, ab223147, Anti-gamma Actin antibody [EPR19353-2] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal gamma Actin antibody. Carrier free. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR19353-2,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab223147 is the carrier-free version of\u003cbr\u003e\nab200046\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGamma actin also known as actin gamma 1 and actin kDa is an essential actin protein found in the cytoskeleton. It is expressed widely in various tissues including muscle and non-muscle cells. This protein has a molecular mass of approximately 42 kDa. Gamma actin plays a mechanical role in maintaining cellular shape and facilitating cell motility by polymerizing into filamentous structures known as F-actin. It has alternate names such as 2a-3' and actin green in some contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGamma actin contributes significantly to the structure of the cytoskeleton affecting cell shape and function. It forms part of actin filament complexes that provide tension and support to the cell. In both muscle and non-muscle cells gamma actin interacts with other actin isoforms to ensure filament stability and elasticity. These interactions are important for processes like cell division signal transduction and cellular transport.\u003cbr\u003e\nPathways\u003cbr\u003e\nGamma actin is involved in pathways related to cell motility and division. This protein is integral to the actin cytoskeleton pathway and has connections with proteins such as profilin and cofilin which regulate actin filament dynamics. Additionally it plays roles in signal transduction pathways that control cellular responses to external signals working alongside proteins like the Rho GTPases.\u003cbr\u003e\nGamma actin has been linked to conditions such as deafness and certain types of cancer. Mutations in the ACTG1 gene encoding gamma actin have been associated with hereditary hearing loss. In cancer changes in gamma actin expression can affect cell migration and invasion contributing to tumor progression. The protein's interaction with other actins and related proteins like actin-binding proteins makes it a critical factor in the molecular mechanisms underlying these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851918659753,"sku":"ab223147","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab223147","provider":"Iright","version":"1.0","type":"link"}