{"product_id":"abcam-ab22352","title":"Abcam, ab22352, PE Anti-CD1a antibody [NA1\/34]","description":"\u003cp\u003eSize: 50Test\u003cbr\u003e\nMouse Monoclonal CD1A antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Cynomolgus monkey, Human samples. Cited in 3 publications. Immunogen corresponding to Cell preparation containing CD1A protein.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:NA1\/34,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nConjugation:PE,\u003cbr\u003e\nExcitation\/Emission:Ex: 480;565nm, Em: 578nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Cynomolgus monkey,\u003cbr\u003e\nApplications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Cell preparation containing CD1A protein. The exact immunogen used to generate this antibody is proprietary information.P06126,\u003cbr\u003e\nSpecificity:ab222352 recognises specifically CD1a expressed by human cortical thymocytes, Langerhans cells, Dendritic cells and a subset of B cells.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nRecommended negative control: Mouse IgG2a Negative Control\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification notes-Purified IgG prepared by ion exchange chromatography, Storage buffer-pH: 7.2Preservative: 0.09% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCD1a also known as T6 antigen or CD1 is a protein with an estimated molecular mass of 37 kDa. It is expressed mainly on the surface of Langerhans cells in the skin and dendritic cells in the thymus. CD1a belongs to the CD1 family which presents lipid antigens to T cells. The protein is an important marker in immunophenotyping of these dendritic cells making it useful in flow cytometry applications.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCD1a participates in the immune system by presenting lipid and glycolipid antigens to T lymphocytes including natural killer T (NKT) cells. It forms a complex with β2-microglobulin which is essential for its proper function and antigen presentation. CD1a expression helps differentiate between types of dendritic cells with CD1a-positive cells often engaging in specific responses to microbial lipid antigens.\u003cbr\u003e\nPathways\u003cbr\u003e\nCD1a plays a significant role in the antigen presentation pathway particularly in lipid antigen presentation to T cells. This is important for initiating immune responses. It interacts with related proteins such as CD1b and CD1c which also present lipid antigens. CD1a has implications in innate and adaptive immunity and can influence pathways involved in microbial recognition and elimination.\u003cbr\u003e\nCD1a is associated with certain skin conditions like Langerhans Cell Histiocytosis and psoriasis. It is involved in the pathogenesis of these diseases by affecting immune responses in the skin. In Langerhans Cell Histiocytosis CD1a-positive cells accumulate abnormally. Additionally CD1a is often studied alongside related proteins like CD207 (Langerin) to understand these conditions better.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855413170345,"sku":"ab22352","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab22352","provider":"Iright","version":"1.0","type":"link"}