{"product_id":"abcam-ab223726","title":"Abcam, ab223726, Anti-PNPLA8 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PNPLA8 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PNPLA8 aa 100-250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PNPLA8 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q9NP80\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPNPLA8 also known as Patatin-like phospholipase domain-containing protein 8 or iPLA2γ is a protein involved in lipid metabolism. It has a molecular mass of approximately 88 kDa. This protein is widely expressed with significant presence in cardiac and skeletal muscle tissues. PNPLA8 plays a role in hydrolyzing phospholipids catalyzing the release of fatty acids which is an important process in cellular lipid metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPNPLA8 participates in the remodeling of membrane phospholipids a process necessary for maintaining cellular membrane integrity and function. It is a part of a larger protein complex that interacts with other enzymes involved in phospholipid metabolism. By facilitating the breakdown of phospholipids PNPLA8 impacts the regulation of signaling lipids which are critical for cellular responses and energy production.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe PNPLA8 protein contributes significantly to the phospholipid signaling and lipid degradation pathways. It plays an essential role in the mitochondrial pathway impacting mitochondrial fatty acid oxidation. PNPLA8 interacts with other proteins involved in these pathways such as PPARα a regulator of fatty acid metabolism highlighting its importance in energy homeostasis and cell signaling processes.\u003cbr\u003e\nPNPLA8 links to metabolic and neuromuscular disorders. Mutations or dysfunctions in PNPLA8 have associations with cardiomyopathy and Barth syndrome due to impaired lipid homeostasis and mitochondrial integrity. PNPLA8 further interacts with tafazzin (TAZ) an enzyme also involved in phospholipid metabolism which connects to the pathogenesis of these disorders. By studying PNPLA8 researchers aim to better understand the molecular basis of lipid-related diseases and explore potential therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854165921961,"sku":"ab223726","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab223726","provider":"Iright","version":"1.0","type":"link"}