{"product_id":"abcam-ab223848","title":"Abcam, ab223848, Anti-Annexin A10\/ANXA10 + Annexin-11\/ANXA11 antibody [EPR19442]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Annexin A10\/ANXA10 antibody. Suitable for WB, IHC-P and reacts with Human, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR19442,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAnnexin A10 (ANXA10) and Annexin-11 (ANXA11) are part of the annexin family of proteins which typically function in phospholipid binding in a calcium-dependent manner. ANXA10 also known as Annexin-62 has a mass of approximately 37 kDa while Annexin-11 weighs around 54 kDa. Expression of ANXA10 mostly occurs in the stomach liver and other parts of the gastrointestinal tract. ANXA11 is widely expressed in the body and found in locations such as the kidney and lungs. These proteins engage in defining cellular processes through their interaction with cell membranes and other cytoplasmic components.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese proteins are key players in cellular functions such as proliferation apoptosis and vesicle trafficking. Annexins often do not work in isolation but as part of complex molecular systems. ANXA10 is considered important in the stabilization of cell membranes while ANXA11 takes on roles in cytokinesis and cell division. Discoveries show that ANXA11 complements cellular dynamics by interacting tightly with other intracellular elements participating actively in a network that regulates cell structure and activity.\u003cbr\u003e\nPathways\u003cbr\u003e\nAnnexins participate directly in signaling pathways involving calcium ions. ANXA10 and ANXA11 are involved in vesicle transport and may also contribute to EGF receptor signaling. Relationships have emerged between these annexins and proteins like actin and tubulin where they assist in maintaining cytoskeletal integrity and dynamics. By modulating response to calcium levels annexins influence how these signaling cascades prompt changes in cellular behavior and responses.\u003cbr\u003e\nAberrations in annexin function link to certain pathologies especially cancer and autoimmune conditions. ANXA10 has associations with gastric cancer where altered expression correlates with disease progression. ANXA11 in contrast connects with amyotrophic lateral sclerosis (ALS) impacting neuronal survival. Studies indicate these annexins do not act alone; their disease relevance relates to their interaction with other proteins. In gastric cancer ANXA10 works in conjunction with molecules like beta-catenin while in ALS ANXA11 involves aggregations affecting protein stability and cell survival.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850358444201,"sku":"ab223848","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab223848","provider":"Iright","version":"1.0","type":"link"}