{"product_id":"abcam-ab224049","title":"Abcam, ab224049, Anti-FARSLA antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal FARSLA antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FARSA aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human FARSA aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q9Y285\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe FARSLA protein also known as phenylalanyl-tRNA synthetase alpha subunit is an essential enzyme in protein synthesis. This protein has a molecular mass of approximately 58 kDa. It is part of the aminoacyl-tRNA synthetase family and catalyzes the attachment of phenylalanine to its corresponding tRNA a critical step in translating mRNA into proteins. FARSLA is expressed widely across various tissues reflecting its fundamental role in cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFARSLA is involved in producing and maintaining the accurate genetic code translation. It operates as part of the heterotetrameric phenylalanyl-tRNA synthetase complex which includes another subunit. This enzyme ensures that phenylalanine is correctly linked to tRNA with its specific anticodon facilitating the incorporation of phenylalanine into growing polypeptide chains during ribosomal assembly.\u003cbr\u003e\nPathways\u003cbr\u003e\nFARSLA functions in the aminoacyl-tRNA biosynthesis pathway a central process required for efficient protein production. This pathway is fundamental to the genetic translation machinery making it essential for cellular life. FARSLA interacts with other aminoacyl-tRNA synthetases like leucyl-tRNA synthetase ensuring high-fidelity translation by linking correct amino acids to their respective tRNA molecules.\u003cbr\u003e\nFARSLA has potential connections to conditions affecting protein synthesis and cellular growth. Mutations or dysregulation of FARSLA are linked to Charcot-Marie-Tooth disease a disorder that impacts peripheral nerves and muscle function. Another related disorder is infantile liver failure syndrome 2 which connects FARSLA with liver dysfunction and metabolic complications. These conditions may involve interactions with other proteins such as tyrosyl-tRNA synthetase highlighting the complex interplay of aminoacyl-tRNA synthetases in human health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854196592809,"sku":"ab224049","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab224049","provider":"Iright","version":"1.0","type":"link"}