{"product_id":"abcam-ab224142","title":"Abcam, ab224142, Anti-Atrophin 1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Atrophin 1 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATN1 aa 500-700.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ATN1 aa 500-700. The exact immunogen used to generate this antibody is proprietary information.P54259\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAtrophin 1 also known by names like Atropin is a protein involved in transcriptional regulation. It has a mass of approximately 230 kDa. This protein exhibits wide expression in the body with detectable levels in neuronal tissues and the brain. Atrophin 1 functions to interact with other proteins influencing gene expression through modulation of chromatin structure.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAtrophin 1 serves essential roles in cellular processes by acting as a transcriptional co-repressor. It participates in developmental functions and neural growth. Atrophin 1 becomes part of protein complexes that alter gene expression by modifying chromatin states. This role connects it with several developmental regulatory networks.\u003cbr\u003e\nPathways\u003cbr\u003e\nAtrophin 1 engages in signaling networks especially those relating to neural development and apoptosis. It interacts within the Notch signaling pathway a significant regulator of cell fate decisions. Atrophin 1 also interfaces with proteins like RBP-Jk facilitating transcriptional output from Notch signaling.\u003cbr\u003e\nAtrophin 1 is tightly associated with Dentatorubral-pallidoluysian atrophy (DRPLA) a neurodegenerative disorder. In DRPLA Atrophin 1 undergoes polyglutamine expansion resulting in protein misfolding and aggregation. The abnormally expanded Atrophin 1 affects neural integrity. Connections with other proteins like huntingtin which also involves polyglutamine expansions hint at shared disease mechanisms and potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854202687657,"sku":"ab224142","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab224142","provider":"Iright","version":"1.0","type":"link"}