{"product_id":"abcam-ab224144","title":"Abcam, ab224144, Anti-cGAS antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal CGAS antibody. Suitable for WB and reacts with Human samples. Cited in 17 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CGAS aa 300-450.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human CGAS aa 300-450. The exact immunogen used to generate this antibody is proprietary information.Q8N884\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe cyclic GMP-AMP synthase commonly referred to as cGAS functions as an enzyme that detects cytosolic DNA. It has a molecular weight of 50 kDa. This protein is widely expressed in various cell types with high expression in cells exposed to foreign DNA such as immune cells. cGAS acts by binding to cytosolic DNA which leads to the production of the secondary messenger cyclic GMP-AMP (cGAMP). This action is critical for initiating innate immune responses against viral infections and cellular stress.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCGAS plays a fundamental role in the immune response by activating the STING pathway. cGAS when bound to DNA forms a complex with DNA as part of its mechanistic function which then catalyzes the synthesis of cGAMP. The cGAMP produced acts as a signaling molecule that activates the STING protein leading to subsequent immune signaling cascades. This activation results in the production of type I interferons and other inflammatory cytokines essential for mounting an effective antiviral response.\u003cbr\u003e\nPathways\u003cbr\u003e\nCGAS operates within important signaling pathways such as the cGAS-STING pathway and the type I interferon pathway. This protein works closely with STING located on the endoplasmic reticulum as a direct effector. The connection between cGAS and STING is important in detecting and responding to cytosolic DNA and initiating immune signaling leading to activation of downstream transcription factors like IRF3 and NF-kB which promote gene expression driving immune responses.\u003cbr\u003e\nCGAS links to autoimmune diseases and cancer. Aberrant cGAS activity can lead to inappropriate immune activation contributing to autoimmune disorders such as lupus where the body attacks its own cells. In the case of cancer cGAS can play dual roles either promoting an immune response against tumors or contributing to an environment where cancer can evade immune detection. The relation between cGAS and diseases also involves STING as disruptions in this pathway can lead to alterations in immune surveillance and inflammation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848650576041,"sku":"ab224144","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab224144","provider":"Iright","version":"1.0","type":"link"}