{"product_id":"abcam-ab224392","title":"Abcam, ab224392, Anti-PTGFRN antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PTGFRN antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTGFRN aa 350-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PTGFRN aa 350-500. The exact immunogen used to generate this antibody is proprietary information.Q9P2B2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPTGFRN also known as Prostaglandin F2 receptor negative regulator is a membrane protein with a mass of approximately 94 kDa. This protein is expressed on various cell types including immune cells like monocytes and macrophages as well as in the heart and lung tissues. PTGFRN interacts with other membrane proteins to modify signalling pathways particularly those involving G-protein-coupled receptors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPTGFRN modulates prostaglandin-mediated signaling serving as a regulatory component that dampens the response to prostaglandin F2 alpha. It is part of a multi-protein complex which includes interactions with proteins like CD9 and integrins. These interactions influence cell adhesion and mobility making PTGFRN relevant in processes like inflammation and tissue repair.\u003cbr\u003e\nPathways\u003cbr\u003e\nPTGFRN plays a significant role in the prostaglandin signaling cascade affecting signal transduction linked with inflammatory responses. It is closely associated with the PI3K\/Akt pathway a critical pathway for cellular survival and proliferation. The interactions between PTGFRN and CD9 or integrins facilitate the integration of signals that modify cell growth and immune function.\u003cbr\u003e\nPTGFRN has been implicated in heart failure and inflammatory lung diseases like chronic obstructive pulmonary disease (COPD). In heart failure PTGFRN can interact with integrins to influence cardiac remodeling and fibrosis. In COPD its regulatory function within the prostaglandin pathway affects inflammatory responses. Understanding these interactions provides insights into potential therapeutic targets for managing these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854352765097,"sku":"ab224392","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab224392","provider":"Iright","version":"1.0","type":"link"}