{"product_id":"abcam-ab224476","title":"Abcam, ab224476, Anti-HBS1L antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal HBS1L antibody. Suitable for WB, ICC\/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HBS1L aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human HBS1L aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9Y450\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHBS1L known also as HBS1-like protein functions as a GTPase associated with translation regulation. It contains motifs essential for GTP binding and hydrolysis. The molecular mass of HBS1L is approximately 73 kDa. Expression of HBS1L can be observed in various tissues with more significance in hematopoietic tissues. It acts as part of cellular machinery involved in maintaining ribosomal integrity and function during translation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHBS1L plays a critical role in retaining the fidelity of mRNA translation by participating in ribosome rescue mechanisms. It forms the SURF complex in association with other proteins like eRF1 and Pelota to release stalled ribosomes and continue protein synthesis. This action helps prevent errors during translation ensuring proper polypeptide formation.\u003cbr\u003e\nPathways\u003cbr\u003e\nHBS1L participates significantly in the ribosome recovery and quality control pathways. It becomes an essential player in the non-stop decay pathway wherein it cooperates with Pelota and ABCE1 proteins. This collaboration reflects its importance in the maintenance of cellular homeostasis by managing defective mRNA decay and ribosomal recycling ensuring effective translation termination when regular processes are interrupted.\u003cbr\u003e\nHBS1L connects notably with beta-thalassemia and sickle cell disease. Its genetic variations often show association with altered fetal hemoglobin levels influencing these conditions. Additionally HBS1L interplays with the BCL11A protein which acts as a repressor of fetal hemoglobin production. This interaction provides insights into potential therapeutic targets for managing hemoglobinopathies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854200950953,"sku":"ab224476","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab224476","provider":"Iright","version":"1.0","type":"link"}