{"product_id":"abcam-ab224687","title":"Abcam, ab224687, Anti-CD96 antibody [EPR22120-174]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CD96 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22120-174,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCD96 also known as TACTILE is an immunoglobulin-like protein weighing approximately 65 kDa. This protein is expressed mostly on T cells and natural killer (NK) cells with its presence also noted on certain leukemic cells. CD96 functions mechanistically as an adhesion molecule mediating interaction between cells significantly involving in immune response modulation. Through binding proteins like CD155 it regulates immune cell migration and activity playing a significant role in cellular communication within the immune system.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe CD96 protein contributes to the immune synapse formation by interacting with other cell surface and intracellular proteins. It is not directly part of a multiprotein complex but closely interacts with the receptor-ligand pairs within immune cell networks. It plays a role in the control of NK cell activity and helps maintain immune homeostasis by balancing activation and inhibition cues.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe CD96 protein significantly impacts immunological pathways particularly those involving T cell and NK cell activation. It connects with pathways such as the DNAM-1 (CD226) and CD155 axis influencing immune cell recognition and response. These pathways regulate cellular activities like cytotoxicity and cytokine production where CD96 collaborates with proteins like DNAM-1 and TIGIT to fine-tune immune responses.\u003cbr\u003e\nCD96 is closely associated with cancer and autoimmune diseases. Its expression level and functional role in cell adhesion and immune response modulation affect tumor immune evasion and surveillance often serving as a potential therapeutic target in cancer immunotherapy. Moreover its interactions with CD155 and DNAM-1 suggest its involvement in autoimmune conditions where regulation of immune cell activity becomes dysregulated pointing towards its relevance in diseases like rheumatoid arthritis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850453373097,"sku":"ab224687","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab224687","provider":"Iright","version":"1.0","type":"link"}