{"product_id":"abcam-ab224825","title":"Abcam, ab224825, Anti-ARL6IP2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ARL6IP2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ATL2 aa 400-450.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ATL2 aa 400-450. The exact immunogen used to generate this antibody is proprietary information.Q8NHH9\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nARL6IP2 also known as ADP-ribosylation-like factor 6 interacting protein 2 is a protein involved in various cellular processes. It has a mass of approximately 25 kDa and is expressed in the endoplasmic reticulum. This protein interacts with lipid-raft-associated proteins playing an important role in membrane dynamics and vesicular trafficking. Researchers have observed it in tissues that exhibit high secretory activity which suggests a function associated with protein transport or modification processes within the cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nARL6IP2 interacts with components of the endoplasmic reticulum to maintain cellular homeostasis and structural integrity. It may be part of larger protein complexes involved in intracellular transport. This protein aids in regulating vesicle formation and trafficking which are essential for efficient cellular communication and nutrient delivery. Its ability to reorganize membrane components allows cells to respond to environmental changes effectively facilitating adaptive responses and cellular survival.\u003cbr\u003e\nPathways\u003cbr\u003e\nARL6IP2 plays a role in the endocytic and secretory pathways. It works alongside other proteins like ARF proteins and clathrin orchestrating trafficking processes that modulate membrane composition and vesicle transport. These pathways are important for normal cellular functioning and involve coordinated interactions with multiple proteins to maintain cellular equilibrium. ARL6IP2's role in these pathways exemplifies its importance in cellular dynamics and intracellular signaling.\u003cbr\u003e\nStudies suggest links between ARL6IP2 and certain neurodegenerative conditions and cancer. Research indicates alterations in ARL6IP2 expression levels might contribute to the progression of diseases like Alzheimer's due to its involvement in cellular trafficking and membrane stability. The protein's connection to disorders often involves interactions with other proteins such as beta-amyloid precursor protein in Alzheimer's indicating its roles in disease mechanisms and pathogenesis. Understanding these interactions provides insights into developing strategies for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854010699945,"sku":"ab224825","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab224825","provider":"Iright","version":"1.0","type":"link"}