{"product_id":"abcam-ab225233","title":"Abcam, ab225233, Alexa Fluor® 647 Anti-IGBP1 antibody [EPR12315]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal IGBP1 antibody - conjugated to Alexa Fluor® 647. Suitable for ICC\/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12315,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nConjugation:Alexa Fluor® 647,\u003cbr\u003e\nExcitation\/Emission:Ex: 650nm, Em: 665nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nAlexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle, Stable for 12 months at -20°C, Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Insulin-like Growth Factor Binding Protein 1 (IGBP1) is a multifunctional protein involved in various cellular processes. It is also known as IGFBP-1 and has a molecular mass of approximately 31 kDa. IGBP1 is widely expressed in human tissues with higher levels detected in the liver and the endometrium. The protein plays a role in modulating the availability of insulin-like growth factors (IGFs) by binding to them affecting their function and stability within the body.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMany cellular processes involve IGBP1 as it binds with insulin-like growth factors to modulate their actions effectively acting as a regulator within the IGF system. IGBP1 may influence cell growth survival and metabolism. It often interacts with other proteins within an IGF-binding complex allowing it to perform various regulatory functions that impact both normal and pathological conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral signaling pathways incorporate the activities of IGBP1 particularly the insulin-like growth factor signaling pathway and the PI3K\/AKT pathway. IGBP1 interacts with other proteins such as IGF1R and IRS-1 affecting downstream signaling that governs aspects of cell proliferation and survival. These interactions position IGBP1 as an important regulatory molecule in these pathways influencing cellular responses to IGFs.\u003cbr\u003e\nResearch has linked abnormal levels or activities of IGBP1 with conditions such as diabetes and cancer. IGBP1's modulation of the insulin-like growth factors may affect insulin sensitivity and glucose metabolism contributing to diabetes pathogenesis. In cancer altered IGBP1 expression can influence tumor growth and progression where its relationship with IGF1 and IGF2 is significant in the context of growth factors and their signaling pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848570425513,"sku":"ab225233","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab225233","provider":"Iright","version":"1.0","type":"link"}