{"product_id":"abcam-ab225646","title":"Abcam, ab225646, Recombinant Human HLA B protein (His tag)","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human HLA B protein (His tag) is a Human Fragment protein, in the 25 to 308 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P01889,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.2 - 7.4Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHLA-B also known as human leukocyte antigen B or HLA-B27 is a protein found in humans that plays a vital role in the immune system. As a type of major histocompatibility complex (MHC) class I molecule HLA-B displays peptide fragments from pathogens on the cell surface alerting cytotoxic T cells. HLA-B has a mass of approximately 45 kDa and is expressed on the surface of almost all nucleated cells including cells in the circulatory and lymphatic systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHLA-B molecules are essential for immune response regulation. They form part of a complex with β2-microglobulin which stabilizes the MHC class I molecule on the cell surface. This complex presents endogenous peptides sourced from intracellular proteins to the T-cell receptor (TCR) of CD8+ T cells. This recognition prompts T cell-mediated cytotoxicity a critical response for the elimination of infected or malignant cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nHLA-B functions within important immune response pathways including the antigen processing and presentation pathway. It works closely with other MHC class I molecules as well as the transporter associated with antigen processing (TAP) proteins that load peptides onto HLA-B for presentation. The pathway also involves proteasomes that generate peptide precursors required for MHC class I molecule loading highlighting HLA-B’s role in the broader immunological framework.\u003cbr\u003e\nHLA-B is notably associated with ankylosing spondylitis and certain types of reactive arthritis. Research shows a strong correlation between HLA-B27 a subtype of HLA-B and these autoimmune diseases indicating a possible role in their pathogenesis. Additionally variations in HLA-B expression and compatibility are significant in tissue transplantation where mismatches can result in transplant rejection involving related proteins such as other HLA molecules and T cell receptors.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843912945833,"sku":"ab225646","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab225646","provider":"Iright","version":"1.0","type":"link"}