{"product_id":"abcam-ab22569","title":"Abcam, ab22569, Anti-Lefty antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Lefty antibody. Suitable for WB, ICC\/IF and reacts with Recombinant full length protein - Human, Recombinant full length protein - Mouse, Human samples. Cited in 10 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody has been tested against recombinant protein only (human LeftyA and mouse Lefty1). I is expected to cross react with Human LeftyB as there is 100% homology of the immunogen with Human LeftyB.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLefty also known as Left-right determination factor is a protein that plays an essential role in the regulation of embryonic development. It comes in two forms: Lefty1 and Lefty2 both of which belong to the TGF-beta superfamily. The molecular mass of Lefty proteins is approximately 38 kDa. These proteins are expressed in various tissues including the heart nervous system and mesoderm during embryogenesis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLefty proteins inhibit specific signaling pathways to control cell fate and patterning during development. They act as antagonists to Activin and Nodal signaling critical components in embryonic patterning. Lefty does not form part of a complex but interacts closely with receptors that mediate the signaling pathways it inhibits. By modulating these pathways Lefty has an important function in ensuring symmetric organ positioning.\u003cbr\u003e\nPathways\u003cbr\u003e\nLefty proteins are involved in the Nodal signaling pathway which is essential for determining the left-right asymmetry in developing embryos. In this pathway Lefty acts against Nodal activity maintaining a balance that is critical for proper organ placement. Other proteins related to this pathway include Smad2 and Smad3 which transduce Nodal signals and are themselves modulated through Lefty activity.\u003cbr\u003e\nDisruptions in Lefty signaling have been associated with abnormal heart and organ development such as situs inversus and heterotaxy syndrome where organs are misplaced or incorrectly oriented. Lefty interacts with Nodal and Activin proteins and anomalies in these interactions can lead to these developmental conditions. Understanding Lefty's role offers potential therapeutic strategies for correcting such congenital disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848651395241,"sku":"ab22569","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab22569","provider":"Iright","version":"1.0","type":"link"}