{"product_id":"abcam-ab226065","title":"Abcam, ab226065, Anti-p60 CAF1\/MPP7 antibody [EPR6105] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal p60 CAF1\/MPP7 antibody. Carrier free. Suitable for IHC-P, IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6105,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt (Intra), WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab226065 is the carrier-free version of\u003cbr\u003e\nab109442\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe target p60 CAF1\/MPP7 also known simply as MPP7 is a protein involved in cellular mechanisms regarding chromatin assembly. It has a mass of approximately 55 kDa. Expression of MPP7 occurs predominantly in the cytoplasm and nucleus. Its function involves association with chromatin assembly factor 1 (CAF-1) complex hence the name p60 CAF1 highlighting its role in DNA replication and repair processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIn cellular environments MPP7 is significant in maintaining cell polarity and epithelial cell junctions. It plays an important part in forming the Crumbs-3 (CRB3) complex an essential component regulating epithelial cell polarity. Through this complex MPP7 collaborates closely with PATJ (Pals1-associated tight junction protein) and DLG1 (Discs Large Homolog 1) contributing to cell junction stability and signal transduction pathways that regulate epithelial integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nMPP7 is integral to epithelial cell polarity pathways and cell adhesion signaling. It affects pathway activities by coordinating with proteins like DLG1 and PATJ. By aligning with the CRB3 complex MPP7 influences processes within the Hippo signaling pathway a pathway that controls cell proliferation and apoptosis. This positions MPP7 as a mediator balancing cell growth and communication in complex signaling networks.\u003cbr\u003e\nMPP7 links to cancer progression and epithelial tissue-related conditions. Due to its role in maintaining cell polarity and structure alterations or disruptions in MPP7 functions could contribute to tumorigenesis. This connection emerges through interactions with PATJ and DLG1 impacting the integrity of epithelial junctions also potentially influencing conditions like Inflammatory Bowel Disease (IBD) where epithelial barrier function is important. Research continues to elucidate the exact mechanisms opening paths for therapeutic targeting in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851741253801,"sku":"ab226065","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab226065","provider":"Iright","version":"1.0","type":"link"}