{"product_id":"abcam-ab226269","title":"Abcam, ab226269, Recombinant OmpA protein (Tagged)","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant OmpA protein (Tagged) is a Haemophilus influenzae Full Length protein, in the 22 to 359 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P45996,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Haemophilus influenzae,\u003cbr\u003e\nStorage buffer:pH: 7.2 - 7.4Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOmpA also known as Outer Membrane Protein A is a significant membrane protein found in many Gram-negative bacteria including Escherichia coli (E. coli). It has a molecular mass of approximately 35 kDa. This protein is expressed in the outer membrane of these bacterial cells. The structure of OmpA includes a beta-barrel that enables it to function as a channel for the passage of small molecules. Its stability and role in maintaining membrane integrity make it an important element of bacterial survival.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOmpA plays a critical role in interactions between the bacterial cell and its environment. It is involved in cell adhesion and invasion influencing the bacterium's ability to establish infection. This protein does not typically exist as part of a larger complex yet it contributes to the structural and functional roles of the bacterial outer membrane. Furthermore it aids in the stabilization of the outer membrane by interacting with other components including lipopolysaccharides.\u003cbr\u003e\nPathways\u003cbr\u003e\nOmpA is integral to bacterial nutrient uptake mechanisms and the response to environmental changes. It participates in the pathway for porin-mediated transport which includes proteins like FepA another outer membrane protein involved in iron transport. Through its channel-forming properties OmpA influences the diffusion of small molecules and ions underlining its involvement in vital processes of cellular homeostasis and response to oxidative stress.\u003cbr\u003e\nOmpA is connected to infectious diseases caused by pathogenic E. coli strains and other Gram-negative bacteria. It serves as a virulence factor contributing to pathogenicity by facilitating the invasion of host cells and evading the immune response. Diseases related to these bacteria such as urinary tract infections (UTIs) demonstrate the importance of OmpA in pathogenicity. OmpA also has connections to proteins like TLR2 (Toll-Like Receptor 2) which recognizes bacterial components and activates immune cell responses linking OmpA to inflammation and immune system modulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843865268393,"sku":"ab226269","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab226269","provider":"Iright","version":"1.0","type":"link"}