{"product_id":"abcam-ab229488","title":"Abcam, ab229488, Anti-RNA polymerase II RPB4 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal RNA polymerase II RPB4 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human POLR2D.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human POLR2D. The exact immunogen used to generate this antibody is proprietary information.O15514\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRNA polymerase II RPB4 also known by the alternate name POLR2D is a subunit of the larger RNA polymerase II enzyme complex. This enzyme plays a critical role in catalyzing the transcription of DNA into messenger RNA (mRNA) which is fundamental to protein synthesis. RPB4 is part of the core enzyme contributing to its stability and function. It has a molecular mass of approximately 25 kDa. This protein is widely expressed in eukaryotic cells particularly in the nucleus where transcription occurs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRNA polymerase II RPB4 functions as a component of the larger RNA polymerase II complex. It contributes to the regulation and initiation of mRNA synthesis. This subunit has essential roles in transcriptional regulation under stress conditions by stabilizing the RNA polymerase II complex. The interaction with co-factors and other transcription machinery highlights RPB4's involvement in adaptive responses of the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nRNA polymerase II RPB4 integrates into essential transcription pathways such as the mRNA processing and the transcription initiation pathway. It cooperates with other subunits and factors like TFIIB and TFIIH to effectively facilitate the transcription process. These pathways determine the accurate transcription and downstream processes necessary for gene expression playing an interconnected role with other proteins like TAFs within the transcriptional machinery.\u003cbr\u003e\nRNA polymerase II RPB4 is associated with several types of cancers as transcription regulation often becomes dysregulated in cancer cells. Disruptions in RPB4 expression or function can also relate to neurodegenerative disorders where transcriptional errors contribute to the disease pathology. Interaction of RPB4 with proteins like p53 may highlight its involvement in these conditions as p53 is a critical regulator of cell cycle and apoptosis often altered in cancerous states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854164381865,"sku":"ab229488","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab229488","provider":"Iright","version":"1.0","type":"link"}