{"product_id":"abcam-ab229951","title":"Abcam, ab229951, Anti-Allergin 1 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal Allergin 1 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MILR1 aa 200 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MILR1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q7Z6M3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAllergin-1 also known as allergine or epityphlon is a membrane protein expressed in myeloid cells particularly mast cells and basophils. The protein has a mass of approximately 50 kDa. Allergin-1 plays a role in signaling processes that regulate immune responses especially those involving allergen recognition and response. This protein contributes to modulating the activation and deactivation of these immune cells helping maintain a balanced immune reaction.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAllergin-1 functions as an inhibitory receptor on myeloid cells. It forms part of a complex with other signaling proteins to suppress excessive immune responses that can lead to allergic reactions. This modulation involves interacting with several intracellular signaling proteins which in turn influence the release of mediators that affect the immune response. Allergin-1 through its inhibitory actions helps prevent over-activation of immune pathways that can contribute to allergic inflammation.\u003cbr\u003e\nPathways\u003cbr\u003e\nAllergin-1 is involved in immune regulatory pathways such as the Fc receptor signaling pathway. It interacts with proteins like Syk kinase and SH2-containing phosphatases contributing to the negative regulation of cell activation. These pathways are key in the immune system's ability to distinguish between harmful and benign stimuli playing a protective role against unwarranted inflammatory responses.\u003cbr\u003e\nAllergin-1 has connections to allergic conditions such as asthma and atopic dermatitis. Allergin-1's ability to modulate immune cell activation can influence the severity and occurrence of these allergic diseases. The protein's interaction with other immune regulators such as SHIP1 demonstrates its importance in managing diseases where exaggerated immune responses occur. Understanding these connections is essential for developing therapeutic strategies aimed at treating allergic disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854195839145,"sku":"ab229951","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab229951","provider":"Iright","version":"1.0","type":"link"}