{"product_id":"abcam-ab230121","title":"Abcam, ab230121, Anti-ZIP-4 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal ZIP-4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC39A4 aa 1-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SLC39A4 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.Q6P5W5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZIP-4 also known as SLC39A4 functions as a zinc transporter responsible for the uptake of zinc ions from the extracellular space into the cytoplasm. It plays a critical role in maintaining zinc homeostasis within the cell. The protein has a molecular mass of approximately 67 kDa. ZIP-4 is predominantly expressed in the small intestine and pancreas where it regulates zinc absorption important for various biological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZIP-4 influences the cellular zinc levels by facilitating zinc influx across the plasma membrane. This transport ensures adequate zinc supply for enzymatic reactions and cellular functions. ZIP-4 does not operate as part of a larger complex but acts independently to regulate zinc entry which impacts cell signaling immune responses and cell proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nZIP-4 participates in the regulation of zinc-dependent pathways such as the MAPK signaling pathway and the NF-kB signaling pathway. These pathways are essential for cell growth survival and immune response. ZIP-4 interacts with other transporters like ZIP-1 and ZIP-10 contributing significantly to the intricate network of zinc homeostasis and cellular regulation.\u003cbr\u003e\nAbnormal ZIP-4 function has links to acrodermatitis enteropathica a rare genetic disorder caused by impaired zinc absorption. This condition causes skin lesions immune dysfunctions and developmental issues. Additionally dysregulation of ZIP-4 has been implicated in certain cancers where increased ZIP-4 expression correlates with tumor growth and metastasis highlighting its relevance in disease pathology and potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854348767401,"sku":"ab230121","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab230121","provider":"Iright","version":"1.0","type":"link"}