{"product_id":"abcam-ab230157","title":"Abcam, ab230157, Anti-FOXC1 antibody [EPR20678] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal FOXC1 antibody. Carrier free. Suitable for IP, WB, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR20678,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab230157 is the carrier-free version of\u003cbr\u003e\nab223850\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFOXC1 also known as Forkhead box C1 is a transcription factor with a molecular mass of approximately 56 kilodaltons. This protein belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. FOXC1 primarily expresses in tissues like the eye brain and kidneys. It plays an important role in regulating gene expression by binding to specific DNA sequences affecting the transcription of genes involved in a variety of cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFOXC1 plays a significant role in the development and differentiation of cells particularly in the anterior segment of the eye and in neural crest-derived tissues. Although it does not usually form part of a larger complex FOXC1 frequently interacts with other transcription factors and co-factors to modulate gene expression. It influences cell proliferation migration and apoptosis ensuring correct tissue and organ formation during development.\u003cbr\u003e\nPathways\u003cbr\u003e\nFOXC1 contributes extensively to the regulation of developmental pathways particularly the Wnt signaling pathway. It also aligns with the Hedgehog signaling pathway which is well-known for its role in developmental processes. FOXC1 often interacts with related proteins such as FOXC2 another forkhead family member that helps orchestrate cellular events during development through these pathways.\u003cbr\u003e\nFOXC1 mutations or dysregulation associate with disorders such as Axenfeld-Rieger syndrome and glaucoma. These conditions highlight the importance of FOXC1 in eye development. FOXC2 often appears in discussions of these conditions due to its shared role in the pathways orchestrating developmental processes. Dysregulation of FOXC1 can also influence factors such as ECM components and signaling molecules leading to pathological changes observed in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850830172329,"sku":"ab230157","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab230157","provider":"Iright","version":"1.0","type":"link"}