{"product_id":"abcam-ab230323","title":"Abcam, ab230323, Anti-ATP6V0C antibody","description":"\u003cp\u003eSize: 200µL\u003cbr\u003e\nRabbit Polyclonal ATP6V0C antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATP6V0C aa 100-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ATP6V0C aa 100-150. The exact immunogen used to generate this antibody is proprietary information.P27449,\u003cbr\u003e\nSpecificity:This ATP6V0C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-126 amino acids from the C-terminal region of human ATP6V0C.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nATP6V0C also known as V-type proton ATPase 16 kDa proteolipid subunit or V0C functions as an integral component of the proton pump that translocates protons across intracellular and plasma membranes. This subunit essential for the assembly and operation of the V-ATPase complex has a mass of approximately 16 kDa. It is widely expressed particularly in cells with high ATP demand such as kidney and brain cells where acid-base balance and nutrient transport are important.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nATP6V0C is a critical player in cellular processes involving pH regulation and vesicular transport. The protein forms part of the V-ATPase complex which contributes to acidification of endosomes lysosomes and the Golgi apparatus. This acidification helps in protein sorting zymogen activation receptor-mediated endocytosis and generation of proton gradients across membranes. As part of this complex ATP6V0C works closely with other subunits to achieve proper function.\u003cbr\u003e\nPathways\u003cbr\u003e\nATP6V0C participates prominently in the endocytic and lysosomal pathways. It plays a role in maintaining the acidity of the lysosomal environment necessary for hydrolase activity. ATP6V0C operates in concert with other proteins such as ATP6V1A and ClC-7 to regulate proton transport and lysosomal function linking it closely to cellular energy metabolism and nutrient sensing pathways.\u003cbr\u003e\nATP6V0C's malfunction associates with conditions such as osteopetrosis and neurodegenerative disorders wherein defective lysosomal acidification leads to impaired cellular function. Osteoclasts responsible for bone resorption rely on ATP6V0C and its associated complex for mineral dissolution. Mutations or dysfunctions in ATP6V0C can lead to disease states by affecting proteins like ATP6V1B2 causing improper acidification and substrate processing within lysosomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850158362793,"sku":"ab230323","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab230323","provider":"Iright","version":"1.0","type":"link"}