{"product_id":"abcam-ab230368","title":"Abcam, ab230368, BAY-299, TAF1 and BRD1 inhibitor","description":"\u003cp\u003eSize: 1mg \/ 5mg \/ 10mg \/ 25mg\u003cbr\u003e\nMW 429.5 Da, Purity \u0026gt;98%. Potent and selective bromodomain inhibitor of TAF1 (IC 50  = 8-13 nM) and BRD1 (IC 50  = 6-67 nM). More than 30-fold selective versus BRD9 and ATAD2. More than 300-fold selective versus BRD4. Inhibits BRD1 (IC 50  = 0.58 μM) and TAF1 (IC 50  = 0.9 μM) binding to Histone H4 in cell-based assays; also inhibits BRD1 (IC 50  = 0.83 μM) and TAF1 (IC 50  = 1.4 μM) binding to Histone H3.3.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:2080306-23-4,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:429.5 Da,\u003cbr\u003e\nMolecular formula:C25H23N3O4,\u003cbr\u003e\nPubChem:122705990,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:100 mM in DMSO,\u003cbr\u003e\nBiochemical name:6-(3-Oxidanylpropyl)-2-(1,3,6-Trimethyl-2-Oxidanylidene-Benzimidazol-5-Yl)benzo[de]isoquinoline-1,3-Dione,\u003cbr\u003e\nBiological description:Potent and selective bromodomain inhibitor of TAF1 (IC50 = 8-13 nM) and BRD1 (IC50 = 6-67 nM). More than 30-fold selective versus BRD9 and ATAD2. More than 300-fold selective versus BRD4. Inhibits BRD1 (IC50 = 0.58 μM) and TAF1 (IC50 = 0.9 μM) binding to Histone H4 in cell-based assays; also inhibits BRD1 (IC50 = 0.83 μM) and TAF1 (IC50 = 1.4 μM) binding to Histone H3.3.,\u003cbr\u003e\nCanonical smiles:CC1=CC2=C(C=C1N3C(=O)C4=C5C(=C(C=C4)CCCO)C=CC=C5C3=O)N(C(=O)N2C)C,\u003cbr\u003e\nInChi:InChI=1S\/C25H23N3O4\/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8-4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31\/h4,7-10,12-13,29H,5-6,11H2,1-3H3,\u003cbr\u003e\nInChiKey:OFWWWKWUCDUISA-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxobenzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847448776873,"sku":"ab230368","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab230368","provider":"Iright","version":"1.0","type":"link"}