{"product_id":"abcam-ab231894","title":"Abcam, ab231894, Anti-AGMAT antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal SPEB antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AGMAT aa 50-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Pig,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human AGMAT aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9BSE5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAGMAT also known as agmatinase is an enzyme that plays a mechanical role in the conversion of agmatine to putrescine by hydrolyzing agmatine. It has a mass of approximately 39 kDa. AGMAT is expressed mainly in the liver kidney and brain where it participates in polyamine biosynthesis which is important for cell growth and differentiation. The presence of AGMAT in different tissues suggests its functional importance in various physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAgmatinase acts as an important enzyme in the metabolism of agmatine an aminoguanidine compound. AGMAT does not function as part of a larger protein complex but rather conducts its enzymatic activity independently. This activity converts agmatine into putrescine a polyamine essential for cellular proliferation genomic stability and modulation of ion channels. By controlling agmatine levels AGMAT has an impact on neurotransmitter systems and may influence both mental and neurophysiological health.\u003cbr\u003e\nPathways\u003cbr\u003e\nFour well-known metabolic and signaling networks incorporate agmatinase activity. The urea cycle and polyamine biosynthesis pathway rely on AGMAT's ability to produce putrescine. In these pathways AGMAT interacts with enzymes such as ornithine decarboxylase which is important for polyamine production. AGMAT regulates these pathways by modulating the availability of substrate and product concentrations balancing cellular responses according to physiological demands.\u003cbr\u003e\nAGMAT influences the progression of certain mental health conditions and inflammatory diseases. In neurological disorders dysregulation of agmatine metabolism links to depression and anxiety with putrescine and its conversion pathways being significant. AGMAT may also interact indirectly with proteins like nitric oxide synthase where altered agmatine levels affect nitric oxide production and inflammatory responses. Researchers explore AGMAT’s modulation as a potential therapeutic avenue to treat these disorders by stabilizing agmatine and polyamine biosynthesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854247973033,"sku":"ab231894","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab231894","provider":"Iright","version":"1.0","type":"link"}