{"product_id":"abcam-ab232416","title":"Abcam, ab232416, Anti-HuD + HuC antibody [EPR19098] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HuD antibody. Carrier free. Suitable for I-ELISA, IP, WB, ICC\/IF, IHC-Fr, Flow Cyt (Intra), IHC-P and reacts with Mouse, Rat, Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR19098,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IP, I-ELISA, ICC\/IF, IHC-P, Flow Cyt (Intra), IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody shows very weak cross reactivity to HuB in WB test. Please contact our Scientific support team for more information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab232416 is the carrier-free version of\u003cbr\u003e\nab184267\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe HuD and HuC proteins also known as neuronal ELAV-like RNA binding proteins play critical roles in neuronal development and function. These proteins weigh approximately 37 kDa and are specifically expressed in neurons. They are part of the family of ELAV (Embryonic Lethal Abnormal Vision) proteins with HuD sometimes referred to as C HuD. HuD and HuC are involved in RNA stabilization processes by binding to AU-rich elements in the 3' untranslated regions (3' UTR) of mRNA which influence the regulation of mRNA turnover stability and translation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHuD and HuC proteins are integral to the regulation of gene expression during neuronal differentiation. They participate in RNA processing machinery and can form complexes with other RNA-binding proteins affecting the neuronal mRNA transcriptome. These interactions facilitate the stabilization and localization of mRNAs essential for synaptic plasticity and neuron functionality. Their presence highlights the post-transcriptional regulation mechanisms vital for nervous system development and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nHuD and HuC proteins are essential players in neuron-specific mRNA processing pathways. They interact closely with molecular pathways involved in learning and memory particularly those involving the MAPK\/ERK pathway. They frequently co-regulate mRNA with other proteins like HuR a ubiquitous ELAV protein. These interactions assist in the modulation of gene expression profiles necessary for proper neuronal signaling and plasticity.\u003cbr\u003e\nHuD and HuC proteins are linked with conditions such as neurological cancer and neurodegenerative disorders. Their deregulation has been associated with neuroblastoma where aberrant expression influences tumor proliferation. Additionally alterations in HuD and HuC protein function have connections with Alzheimer's disease wherein their interactions with tau protein impact disease progression. Understanding these associations provides insights into potential therapeutic targets and interventions for such conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851598745769,"sku":"ab232416","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab232416","provider":"Iright","version":"1.0","type":"link"}