{"product_id":"abcam-ab232466","title":"Abcam, ab232466, Anti-ARTS1\/ERAP1 antibody [EPR6069] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ARTS1\/ERAP1 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6069,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The mouse and rat recommendation is based on the WB results. We do not guarantee IHC-P for mouse and rat.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab232466 is the carrier-free version of\u003cbr\u003e\nab124669\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nARTS1 also known as ERAP1 (Endoplasmic Reticulum Aminopeptidase 1) is an aminopeptidase enzyme with a molecular mass of about 110 kDa. This protein is located in the endoplasmic reticulum and plays a significant mechanical role in trimming peptides for presentation by MHC class I molecules. Its expression is highly detectable in cells with robust antigen-presenting capabilities such as dendritic cells and macrophages. Additionally ARTS1\/ERAP1 exists in other tissues where immune surveillance is essential.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe function of ARTS1\/ERAP1 involves the processing of proteolytic fragments preparing them for optimal binding to MHC class I molecules. This enzyme participates in a complex alongside ERAP2 another aminopeptidase working cooperatively to adjust peptide lengths to the correct size necessary for MHC class I presentation. Through this role ARTS1\/ERAP1 influences the immune system's ability to detect and respond to infected or neoplastic cells by ensuring that antigenic peptides are properly presented.\u003cbr\u003e\nPathways\u003cbr\u003e\nARTS1\/ERAP1 is a critical component of the antigen processing and presentation pathway. This pathway is essential for the presentation of endogenous antigens to cytotoxic T lymphocytes therefore playing a role in adaptive immunity. Related proteins include MHC class I molecules which present the processed peptides and TAP (Transporter associated with Antigen Processing) which transports peptides into the endoplasmic reticulum for further trimming by ARTS1\/ERAP1.\u003cbr\u003e\nResearch links ARTS1\/ERAP1 to ankylosing spondylitis and other autoimmune diseases. Variations in the ERAP1 gene may affect peptide trimming efficiency altering the peptide repertoire presented by MHC class I molecules and influencing autoimmune activation. The link to another protein HLA-B27 is notable in ankylosing spondylitis as this MHC class I allele frequently associates with the disease highlighting a complex interaction between ARTS1\/ERAP1 enzymatic function and autoimmune susceptibility.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851602645161,"sku":"ab232466","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab232466","provider":"Iright","version":"1.0","type":"link"}