{"product_id":"abcam-ab232600","title":"Abcam, ab232600, Anti-TMEM192 antibody [EPR14330-67] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nAnti-TMEM192 antibody [EPR14330-67] - BSA and Azide free (ab232600) is a rabbit recombinant monoclonal antibody provided in a PBS only buffer for easy conjugation detecting TMEM192 in  Western Blot, Flow Cytometry . Suitable for  Human . - BSA, sodium azide, and glycerol-free for easy conjugation - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14330-67,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-TMEM192 antibody [EPR14330-67] - BSA and Azide free (ab232600) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt) in Human samples.\u003cbr\u003e\nWhat is the molecular weight of TMEM192?\u003cbr\u003e\nAnti-TMEM192 [EPR14330-67] - BSA and Azide free (ab232600) specifically detects a band for TMEM192 (UniProt: Q8IY95) at a molecular weight of 31kDa.\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR14330-67] also available for your convenience:\u003cbr\u003e\nab186737\u003cbr\u003e\n, Carrier free - ab232600\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTMEM192 also known as Transmembrane Protein 192 has a molecular weight of approximately 25 kDa. It is a lysosomal membrane protein expressed in various tissues including the spleen and thymus. This protein predominantly localizes to the lysosomal compartment where it plays a role in maintaining lysosomal integrity. Researchers often study TMEM192 for its role in membrane stabilization and its interaction with other lysosomal proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTMEM192 participates in the regulation of lysosomal functions. It integrates into the lysosomal membrane and contributes to the stability and function of this organelle. While not commonly part of larger protein complexes it influences lysosomal enzymatic activities by stabilizing the lysosomal environment. Its role in regulating pH and transport processes within the lysosome directly affects how the cell processes cellular debris and macromolecules.\u003cbr\u003e\nPathways\u003cbr\u003e\nTMEM192 interacts with cellular processes related to lysosomal biogenesis and autophagy. It functions closely with lysosomal-associated membrane protein 1 (LAMP1) within the lysosomal pathway which plays a critical role in the degradation and recycling of cellular components. The lysosomal pathway where TMEM192 operates is significant for maintaining cellular homeostasis by regulating autophagic activity and responding to nutrient availability.\u003cbr\u003e\nDisruptions in TMEM192 function associate with lysosomal storage disorders. Altered expression or mutations in TMEM192 link to Niemann-Pick disease type C which involves the accumulation of lipids within lysosomes. LAMP1 a protein associated with TMEM192 also plays a part in this disease pathway contributing to understanding the mechanism of lysosomal dysregulation in Niemann-Pick and similar disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851907387561,"sku":"ab232600","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab232600","provider":"Iright","version":"1.0","type":"link"}