{"product_id":"abcam-ab232833","title":"Abcam, ab232833, Anti-GSTA2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal GSTA2 antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Gsta2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Mouse Gsta2.P10648\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein Glutathione S-transferase alpha 2 (GSTA2) plays an important mechanical role in detoxification processes. GSTA2 belongs to the family of glutathione S-transferases and has a mass of approximately 25 kDa. This enzyme is known for catalyzing the conjugation of the reduced form of glutathione to various substrates aiding in their solubility and subsequent excretion from the body. GSTA2 is mainly expressed in the liver but it can also be found in other tissues such as the kidney and intestine exposed to oxidative stress and toxicants.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGSTA2 contributes significantly to protecting cells from oxidative damage and chemical stress. It does not form part of a larger protein complex but acts as an important defense line in detoxifying endogenous and exogenous compounds. The presence of GSTA2 ensures the maintenance of cellular redox balance by eliminating harmful electrophiles and peroxides that could cause cellular damage.\u003cbr\u003e\nPathways\u003cbr\u003e\nGSTA2 is an essential component of the drug metabolism and glutathione conjugation pathways. In these pathways it cooperates with other glutathione S-transferases to facilitate the transformation of toxic substances into less harmful compounds. GSTA2 shares functional similarities with proteins like GSTP1 which also participate in the glutathione transferase activity under stressful environmental conditions. These pathways ensure cellular resilience against chemical insults maintaining homeostasis and cellular function.\u003cbr\u003e\nGSTA2 has notable connections to cancer and liver disease. Research shows changes in GSTA2 expression levels in various cancers where altered detoxification processes contribute to tumor development and progression. In liver diseases varying GSTA2 activities influence the liver’s ability to manage oxidative stress and perform detoxification. GSTA2 shows interaction with proteins such as CYP enzymes which are also involved in drug and xenobiotic metabolism influencing disease outcomes and treatment responses.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854380421289,"sku":"ab232833","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab232833","provider":"Iright","version":"1.0","type":"link"}