{"product_id":"abcam-ab232896","title":"Abcam, ab232896, Anti-HDLBP antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal HDLBP antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Pig, Recombinant full length protein - Human, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HDLBP aa 150-400.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Pig,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human HDLBP aa 150-400. The exact immunogen used to generate this antibody is proprietary information.Q00341\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab232896 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe HDLBP also known as Vigilin is a protein that interacts with high-density lipoproteins (HDL). It has a molecular mass of approximately 116 kDa. HDLBP plays an important role in binding RNA and is largely expressed in the liver and adipose tissues. Through its RNA-binding capacity HDLBP regulates the stability and translation of specific mRNAs impacting various cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nWithout HDLBP's regulatory functions in RNA metabolism cells struggle to maintain proper gene expression. This protein is not known to operate as part of a multi-protein complex but acts independently to influence RNA molecule interactions. HDLBP regulates lipid metabolism by facilitating the transport and stabilization of RNA species that encode enzymes important for lipid synthesis and uptake.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe RNA-binding functions of HDLBP integrate into lipid metabolism and transport pathways. In the lipid metabolic pathway HDLBP interacts with other proteins such as apolipoproteins to manage lipid homeostasis. In addition it plays a part in the RNA processing and transport pathway linking its activity to proteins involved in RNA export and translation control.\u003cbr\u003e\nWithout balanced HDLBP activity individuals show an increased risk of developing atherosclerosis and metabolic syndrome. The improper regulation of HDL and lipid metabolism contributes to these conditions. HDLBP's role overlaps with the functions of apolipoprotein A-I in these disorders as both participate in managing HDL-cholesterol levels and lipid homeostasis. Understanding HDLBP's mechanisms can help target therapeutic strategies for cardiovascular diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854096027817,"sku":"ab232896","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab232896","provider":"Iright","version":"1.0","type":"link"}