{"product_id":"abcam-ab232963","title":"Abcam, ab232963, Anti-GPT2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal GPT2 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GPT2 aa 200-300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Pig,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human GPT2 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.Q8TD30\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe GPT2 protein also known as Glutamyl-Prolyl-tRNA Synthetase 2 is an enzyme essential for the translation process in protein biosynthesis. It functions by charging tRNA molecules with their respective amino acids specifically glutamic acid and proline. The GPT2 protein has a mass of approximately 170 kDa and is expressed in various tissues including muscles and kidneys. This widespread expression suggests its significant role in maintaining protein synthesis in different cellular environments.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGPT2 enzyme plays an important role in catalyzing the attachment of amino acids to their corresponding tRNA molecules a vital step in ribosomal protein synthesis. As part of the aminoacyl-tRNA synthetases GPT2 forms a complex with other synthetases to ensure accurate decoding of mRNA during translation. These complexes are essential for preserving translational fidelity across diverse biological systems impacting numerous cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe GPT2 enzyme integrates into the translation pathway where it ensures efficient and precise protein synthesis. Its activity connects closely with the mTOR signaling pathway which regulates cell growth and metabolism in response to nutritional status. GPT2 interacts with other tRNA synthetases and translation initiation factors forming a critical component of the protein synthesis mechanism. This highlights its coordination with other proteins to uphold proper cellular function.\u003cbr\u003e\nGPT2 has associations with certain mitochondrial diseases due to defects in protein synthesis and metabolism. Errors or mutations in tRNA synthetases including GPT2 can lead to mitochondrial dysfunction and related disorders such as Charcot-Marie-Tooth disease. This connection implicates GPT2 and other proteins in its group like glycyl-tRNA synthetase in these neuropathological conditions. Understanding these associations can facilitate the development of targeted therapies for related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854386057385,"sku":"ab232963","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab232963","provider":"Iright","version":"1.0","type":"link"}