{"product_id":"abcam-ab233438","title":"Abcam, ab233438, Anti-Raftlin antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Raftlin antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RFTN1 aa 250-550.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human RFTN1 aa 250-550. The exact immunogen used to generate this antibody is proprietary information.Q14699\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRaftlin also known as RFTN1 is an important glycoprotein in cellular mechanics. It has a molecular mass of approximately 180 kDa. Raftlin is broadly expressed in various cell types including immune and epithelial cells. It plays a role mainly in cell membrane components often found in lipid rafts contributing to signal transduction processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRaftlin plays a significant role in immune system functioning. It is important in the formation and stability of lipid rafts specialized membrane microdomains that facilitate efficient signaling. Raftlin associates with the B-cell receptor complex stabilizing complex formation and affecting antibody-mediated immune responses. Through these interactions Raftlin influences the cellular signaling cascade essential for proper immune defense.\u003cbr\u003e\nPathways\u003cbr\u003e\nRaftlin integrates into key immune signaling routes such as the B cell receptor (BCR) signaling pathway. It modulates the recruitment and assembly of signaling molecules influencing pathways like NF-kB essential for immune cell activation. Raftlin interacts with proteins like Lyn and Syk important for signal propagation within these pathways enhancing immune response regulation.\u003cbr\u003e\nRaftlin is linked to immune-related conditions such as autoimmune diseases. It associates with proteins like CD19 and plays a part in dysregulated BCR signaling which can contribute to pathologies such as lupus. Alterations in Raftlin expression or function can impact immune tolerance and lead to improper immune system activation thereby driving disease processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854380716201,"sku":"ab233438","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab233438","provider":"Iright","version":"1.0","type":"link"}