{"product_id":"abcam-ab233757","title":"Abcam, ab233757, Anti-IL-9R antibody [4A11H2]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal IL-9R antibody. Suitable for Flow Cyt, WB and reacts with Human, Rat samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IL9R aa 1-300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:4A11H2,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human IL9R aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q01113\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nInterleukin 9 receptor (IL-9R) also known as CD129 is a transmembrane protein that belongs to the cytokine receptor family. It weighs approximately 54 kDa. IL-9R is expressed on various cell types including T cells B cells mast cells and certain epithelial cells. This receptor primarily binds to interleukin 9 (IL-9) and forms a heterodimer with the common gamma chain a component shared with other interleukin receptors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIL-9R plays essential roles in immune system signaling and regulation. As part of a receptor complex it activates downstream signaling pathways upon IL-9 binding influencing the immune responses such as cell survival proliferation and differentiation. IL-9R is also known to modulate allergic inflammation and has effects on both innate and adaptive immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearch indicates that IL-9R is a participant in the JAK\/STAT signaling pathway. This pathway includes janus kinase 1 (JAK1) and signal transducer and activator of transcription 5 (STAT5) both important for transmitting signals from IL-9 to exert cellular effects. IL-9R also connects to pathways involving other immune-modulating interleukins suggesting its broad role in immune regulation.\u003cbr\u003e\nIL-9R holds a significant relationship with asthma and allergic diseases. It plays a role in promoting inflammatory responses in the airways related to conditions like asthma. Moreover IL-9R has connections with IL-13 in the context of allergic inflammation and this interaction may amplify disease pathology. Understanding the dynamics of IL-9R could offer insights into therapeutic targets for managing such immune-related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854748733609,"sku":"ab233757","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab233757","provider":"Iright","version":"1.0","type":"link"}