{"product_id":"abcam-ab234422","title":"Abcam, ab234422, Anti-ANO6 antibody [EPR20910-105]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ANO6 antibody. Suitable for IP, WB and reacts with Mouse, Rat samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR20910-105,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAnoctamin 6 also known as ANO6 TMEM16F or NGEP is a protein that functions mechanically as a calcium-activated chloride channel and scramblase. It plays a role in phospholipid scrambling across the plasma membrane influencing membrane stability and shape. ANO6 has a mass of approximately 114 kDa. Researchers have detected ANO6 in a variety of tissues with higher expression noted in the heart skeletal muscles and testis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nANO6 is involved in critical cellular processes such as apoptosis and blood coagulation. This protein contributes to the externalization of phosphatidylserine a process necessary during cell death and platelet activation. ANO6 does not strictly function alone; it often interacts with other members of the TMEM16 family forming complexes that modulate its functional specificity and activity.\u003cbr\u003e\nPathways\u003cbr\u003e\nANO6 is integral to the extrinsic pathway of apoptosis and the process of blood coagulation. It plays a role in regulating cell membrane ion homeostasis working alongside related proteins such as ANO1 and ANO2. These pathways maintain the stability and balance of cellular environments influencing processes like cell shrinkage and coagulative events.\u003cbr\u003e\nANO6 relates to conditions like Scott syndrome a bleeding disorder characterized by defective phosphatidylserine exposure on platelets and can impact certain cardiac arrhythmias. ANO6's role in these disorders often involves interaction with other regulatory proteins such as phospholipase C which impacts phospholipid signaling and platelet function. Understanding ANO6's involvement in these processes aids in developing potential therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850334458025,"sku":"ab234422","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab234422","provider":"Iright","version":"1.0","type":"link"}