{"product_id":"abcam-ab234847","title":"Abcam, ab234847, Anti-TRIM13 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TRIM13 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM13 aa 1-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TRIM13 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.O60858\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRIM13 also known as RFP2 is a protein encoded by the TRIM13 gene with an approximate mass of 42 kDa. Mechanically TRIM13 functions as an E3 ubiquitin ligase mediating ubiquitination and proteasomal degradation. It belongs to the tripartite motif family characterized by a RING zinc finger one or more B-box domains and a coiled-coil region. The protein is expressed in various tissues including the heart liver and pancreas suggesting a wide range of functional roles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein is important for maintaining cellular homeostasis by regulating protein turnover and quality control. TRIM13 is involved in the endoplasmic reticulum-associated degradation (ERAD) pathway where it facilitates the removal of misfolded proteins. Additionally it interacts with other molecules to form complexes that modulate autophagy a process vital for cellular cleaning and response to stress.\u003cbr\u003e\nPathways\u003cbr\u003e\nUbiquitination processes and quality control systems incorporate TRIM13 into the intricacies of the ERAD and autophagy pathways. It coordinates with proteins like p62 and Beclin1 which are important for autophagy regulation. In the ERAD pathway TRIM13 functions alongside components such as Derlin-1 helping to identify and direct aberrant proteins toward degradation. These interactions balance protein synthesis and degradation essential for cellular stress responses and survival.\u003cbr\u003e\nTRIM13's roles tie to neurodegenerative diseases and cancer. Mutations or dysregulation of TRIM13 lead to an accumulation of misfolded proteins contributing to the progression of amyotrophic lateral sclerosis (ALS). In cancer altered TRIM13 expression can disrupt normal degradation processes affecting tumor growth and metastasis. TRIM13 interacts with CHOP a protein involved in pro-apoptotic signaling which links it to cellular stress responses that are pivotal in disease states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854367609001,"sku":"ab234847","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab234847","provider":"Iright","version":"1.0","type":"link"}