{"product_id":"abcam-ab235444","title":"Abcam, ab235444, Anti-Quiescin Q6 antibody [EPR21866]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Quiescin Q6 antibody. Suitable for IP, WB, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR21866,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-P, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nQuiescin Q6 also known as QSOX1 is an enzyme belonging to the Quiescin-sulfhydryl oxidase family. It functions by catalyzing the oxidation of sulfhydryl groups to form disulfide bonds in proteins an important step for proper protein folding. QSOX1 has a molecular mass between 60-100 kDa depending on its isoform. This protein is expressed in various tissues with high levels present in the pancreas placenta and some cancer cells suggesting a role in tissue specific processes and during certain pathological conditions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nQuiescin Q6 influences cell growth and differentiation. The protein is involved in extracellular matrix organization where it plays a role in maintaining the stability and function of connective tissues. It doesn't typically assemble into large complexes but interacts with substrates directly facilitating the formation of stable proteins. QSOX1 ensures that proteins achieve their functional conformation by reshaping their disulfide bonds efficiently aiding in the cellular machinery of protein conformation.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe functions of Quiescin Q6 intersect with the protein folding and oxidative stress response pathways. It relates closely to the endoplasmic reticulum protein folding pathway due to its role in disulfide bonding as well as to the antioxidant defense pathway where it mediates protection against oxidative stress. Its activity connects with proteins such as protein disulfide isomerase (PDI) which also participate in creating disulfide bonds but at different stages or cellular locations showcasing distinct but cooperative functions within these pathways.\u003cbr\u003e\nQuiescin Q6 has been linked to cancer progression and fibrosis. Its overexpression has been observed in various tumors indicating a potential role in tumor growth and metastasis. In fibrotic diseases elevated levels of QSOX1 contribute to excessive extracellular matrix deposition. It connects with the transforming growth factor-beta (TGF-beta) pathway a critical regulator in fibrosis and cancer where QSOX1's regulation of matrix composition may influence TGF-beta signaling. Understanding these connections offers potential for developing targeted therapeutic strategies in treating related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850379546793,"sku":"ab235444","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab235444","provider":"Iright","version":"1.0","type":"link"}