{"product_id":"abcam-ab235456","title":"Abcam, ab235456, Lifitegrast, LFA-1 (lymphocyte function-associated antigen-1) antagonist","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 615.48 g\/mol, Purity \u0026gt;98%. LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is designed to mimic the binding epitope of ICAM-1. It acts as a molecular decoy to block the LFA-1\/ICAM-1 interaction and thus inhibits downstream inflammatory responses.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1025967-78-5,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:615.48 g\/mol,\u003cbr\u003e\nMolecular formula:C29H24Cl2N2O7S,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:DMSO \u0026gt;30 mg\/mLEthanol 20 mg\/mLInsoluble in water,\u003cbr\u003e\nBiological description:LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is designed to mimic the binding epitope of ICAM-1. It acts as a molecular decoy to block the LFA-1\/ICAM-1 interaction and thus inhibits downstream inflammatory responses.,\u003cbr\u003e\nCanonical smiles:CS(=O)(=O)C1=CC=CC(=C1)CC(C(=O)O)NC(=O)C2=C(C=C3CN(CCC3=C2CL)C(=O)C4=CC5=C(C=C4)C=CO5)CL,\u003cbr\u003e\nInChi:InChI=1S\/C29H24Cl2N2O7S\/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18\/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)\/t23-\/m0\/s1,\u003cbr\u003e\nInChiKey:JFOZKMSJYSPYLN-QHCPKHFHSA-N,\u003cbr\u003e\nIUPAC Name:(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B1917 Lifitegrast. B1917-25 is the same size as the 25 mg size of ab235456.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847496814761,"sku":"ab235456","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab235456","provider":"Iright","version":"1.0","type":"link"}