{"product_id":"abcam-ab235810","title":"Abcam, ab235810, Recombinant Human NPR-A protein (Tagged)","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human NPR-A protein (Tagged) is a Human Fragment protein, in the 33 to 473 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P16066,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.2 - 7.4Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPreviously labelled as Natriuretic Peptide Receptor A.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNPR-A also known as natriuretic peptide receptor A is a guanylyl cyclase-linked receptor with a mass of approximately 120 kDa. It largely expresses in the kidney heart adrenal gland and vascular smooth muscle cells. NPR-A is structured to bind specifically with atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) facilitating signal transduction. This receptor generates cyclic GMP (cGMP) upon activation which acts as a secondary messenger in various cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNatriuretic peptide receptor A plays a significant role in cardiovascular homeostasis. NPR-A is not part of a larger complex but works closely with other natriuretic peptide systems to regulate blood pressure electrolyte balance and fluid homeostasis. Its activation results in diuresis natriuresis and vasodilation contributing to its function in maintaining cardiovascular health. Efficient functioning of NPR-A is essential for modulating cardiovascular responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nNPR-A is important in the cyclic GMP pathway and the ANP signaling pathway. It interacts with proteins like NPR-C and soluble guanylyl cyclase modulating key physiological responses. NPR-A impacts smooth muscle relaxation and renal function by influencing cGMP levels and related downstream pathways. Its role within these pathways is fundamental to maintaining vascular tone and sodium excretion.\u003cbr\u003e\nNPR-A associates prominently with cardiovascular diseases such as hypertension and heart failure. In hypertension NPR-A dysregulation can impair proper sodium and water excretion exacerbating the condition. Heart failure involves altered signaling of NPR-A impacting cardiac and renal function. Protein interactions include altered expression of NPR-C affecting natriuretic peptide clearance and disease progression. Understanding NPR-A's function and regulation provides insights into its relationship with cardiovascular pathophysiology and potential therapeutic approaches.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843867857065,"sku":"ab235810","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab235810","provider":"Iright","version":"1.0","type":"link"}