{"product_id":"abcam-ab236134","title":"Abcam, ab236134, Anti-CAPON\/NOS1AP antibody [EPR14519(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal CAPON\/NOS1AP antibody. Carrier free. Suitable for WB, ICC\/IF, Flow Cyt (Intra) and reacts with Mouse, Rat, Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14519(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab236134 is the carrier-free version of\u003cbr\u003e\nab190686\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCAPON also known as NOS1AP (nitric oxide synthase 1 adaptor protein) is an adaptor protein with a molecular weight of about 55 kDa. This protein interacts primarily with neuronal nitric oxide synthase (nNOS) modulating its activity. CAPON is expressed in the brain particularly in regions like the hippocampus and cerebral cortex where it plays roles in neuronal signaling. Its involvement in the brain implies its importance in neural functions and cognitive processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCAPON influences signal transduction processes involving nitric oxide. As part of a molecular complex it binds with nNOS which leads to the modulation of nitric oxide production. This regulation impacts synaptic plasticity and neurotransmission hence affecting learning and memory. By interacting with other signaling proteins CAPON can affect the cellular response to various stimuli making it a significant player in neuronal communication.\u003cbr\u003e\nPathways\u003cbr\u003e\nCAPON’s function fits into the nitric oxide signaling pathway which is important for neuron communication and vasodilation processes. It associates with the ERK\/MAPK pathway which plays a role in cognition and neural development. Through nitric oxide modulation it influences other proteins such as PSD95 a postsynaptic density protein which impacts synaptic organization and function. This involvement showcases its role in maintaining neuronal integrity and function within these pathways.\u003cbr\u003e\nCAPON has ties to neurologic and psychiatric conditions specifically schizophrenia and bipolar disorder. Alterations in its interaction with nNOS have been linked to the pathophysiology of these conditions. Additionally CAPON's connection with proteins like PSD95 suggests it may impact synaptic organization which can be disrupted in such mental health disorders. Understanding CAPON’s role could contribute to therapeutic approaches in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851738501289,"sku":"ab236134","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab236134","provider":"Iright","version":"1.0","type":"link"}