{"product_id":"abcam-ab236408","title":"Abcam, ab236408, Anti-RFXANK antibody [OTI3E7]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nMouse Monoclonal RFXANK antibody. Suitable for IHC-P, WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human, Transfected cell lysate - Human, Transfected cell line - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RFXANK.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:OTI3E7,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human RFXANK.O14593\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nClone OTI3E7 (formerly 3E7).\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe RFXANK protein also known as regulatory factor X-associated ankyrin-containing protein is a component of the RFX complex. RFXANK has a molecular mass of approximately 27 kDa. This protein plays a mechanical role in the regulation of transcription by interacting with DNA sequences and recruiting various co-factors necessary for gene expression. RFXANK is largely expressed in immune cells where it modulates processes important for immune function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRFXANK acts as part of the RFX complex which is known for its role in the regulation of class II major histocompatibility complex (MHC) genes. These genes are significant for proper immune response allowing immune cells to present antigens and initiate defense mechanisms. RFXANK through its interaction with other proteins like RFX5 and RFXAP stabilizes the DNA binding ability of the RFX complex enabling the transcription of genes essential for antigen presentation.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe regulatory influence of RFXANK integrates into important immune pathways such as the MHC class II antigen presentation pathway. RFXANK's partnership with RFX5 and RFXAP facilitates binding to the X-box motif of MHC class II promoters ensuring the transcription initiation required for effective immune surveillance. These relations evidence RFXANK's vital place in immune system operations particularly in adaptive immunity.\u003cbr\u003e\nRFXANK mutations or dysregulation relate to bare lymphocyte syndrome type II a severe immunodeficiency disorder. This condition arises when RFXANK fails to properly regulate MHC class II expression compromising antigen presentation and adaptive immune response. Connections exist between RFXANK and other disease-related proteins like RFX5 which highlight disruptions at the molecular level impacting immune functionality.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855481360553,"sku":"ab236408","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab236408","provider":"Iright","version":"1.0","type":"link"}